The colon and stomach are the most common primary tumors to result in ovarian metastases, followed by the breast, lung, and contralateral ovary. If you have problems viewing pdf files, download the latest version of adobe. On microscopic examination, composed of cells with clear cytoplasm that contains glycogen hob nail cells. Krukenberg tumor is an uncommon metastatic tumor of the ovary. Kt is related to severe prognosis due to its aggressiveness, diagnostic difficulties and poor treatment efficacy. The term krukenberg tumor, from its eponymic description 1, refers to ovarian lesions with sarcomatous stroma and mucincontaining signetring cells.
Ovarian cancer occurs in one in 8000 to one in 25,000 pregnancies. Krukenberg tumors definition of krukenberg tumors by. Hi there, my mother is 52 years old, she was diagnosed in sept. In most cases, the cancer starts from the ovary itself while in few cases accounting for 1 to 2% of the total, the cancer metastasizes into the ovary. This case report concerns a 25yearold pregnant woman referred at 24 weeks of gestation with an ovarian tumor. A total of 156 consecutive patients diagnosed with kts of the ovary.
Symptoms, risk factors and treatments of krukenberg tumor medical condition a krukenberg tumor refers to a malignancy in the ovary that metastasized from a. All stage iv stomach cancer krukenberg tumours messages. Metastatic tumors, except for krukenberg tumors, show the various pathologic findings in. Signs and symptoms most patients with gastric cancer are symptomatic. It accounts for 30%40% of metastatic cancers to the ovaries and possibly 1%2% of all malignant ovarian tumors. Krukenberg tumor is a metastatic cancerous development spread from stomach to ovary. A krukenberg tumor from an occult intramucosal gastric. Most of these tumors arise in the gastrointestinal tract although the term krukenberg tumor has also been used more loosely to describe metastatic disease to the ovary from other sites such as breast and genital tract. Several treatments have been used, such as cytoreductive surgery crs, adjuvant chemotherapy ct andor hyperthermic intraperitoneal chemotherapy hipec.
The primary lesion of krukenberg tumor is frequently from stomach but may also be from colon, biliary tract, appendix, breast and gall bladder. It is characterized by areas of mucoid degeneration and the presence of signetringlike cells. Clear cell carcinoma clear cell ovarian tumors are part of the surface epithelial tumor group of ovarian cancers, accounting for 6% of these cancers. Of the 43 patients, the median age at diagnosis of krukenberg tumor was 42 years range, 2172. Pdf gastric cancer, one of the most common cancers in the world, rarely metastasizes to the ovaries. The tumor was named by freidrich ernst krukenberg, a german pathologist who, in 1896, first described the new ovarian tumor as. When the primary tumor is not found, the distinction between a metastatic tumor from an occult cancer and a primary krukenberg tumor is challenging. Krukenberg tumor in a 22 year old patient with primary tumor in the transverse colon. Carcinomas of colon, appendix, and breast mainly invasive lobular carcinoma are the next most common primary sites. A tumor of the ovary that is caused by the spread of metastatic cancer of the gastrointestinal tract. The lobster claw for traumatic amputation of the left hand surath amarnath, mettu rami reddy, chayanam hanumantha rao, anadarao venkata dakshina murthy department of orthopaedics, nri medical college and general hospital, chinakakani, guntur, andhra pradesh, india. A krukenberg tumor is a rare and potentially deadly cause of elevated serum. The majority of patients with krukenberg tumor remain asymptomatic or have nonspecific gastrointestinal symptoms.
Pdf pseudomeigs syndrome caused by a krukenberg tumour. Recently, the term krukenberg tumor has been used more widely and loosely to describe any metastatic lesion to the ovary. Computed tomography showed the presence of a thoracic mass. In order to analyze the clinical characteristics and prognostic factors, we retrospectively investigated 128 patients who were diagnosed with krukenberg tumor between january, 1990 and december, 2010.
Stomach is the primary site in most krukenberg tumors 70%. This study aimed to identify the prognostic factors affecting the survival of patients with kts of colorectal origin who receive cytoreductive surgery. Krukenberg tumor without leaving macroscopic residual lesions is difficult in many cases, and it has been reported that the median duration of survival ranges from 7. Krukenberg tumor is an uncommon metastatic tumor of ovary. Although krukenberg tumor can occur in people of all age groups, the average age is fixed at 45 years. The aim of this paper is to report an unusual such case in which almost complete dysphagia and ureteral stenosis occurred. Krukenberg tumor kt is a rare secondary ovarian tumor, primarily localized at the gastrointestinal tract in most cases.
Krukenberg tumor is a rare metastastic tumor of the ovary, characterized by poor prognosis. Krukenberg tumor is metastatic and it accounts for 1% to 2% of ovarian tumors. The overall survival in our patients was two months. Approximately 25 percent of patients with gastric cancer have a history of gastric ulcer. Krukenberg tumors from pulmonary adenocarcinoma represent an extremely rare situation. The 62yearold patient was initially investigated for dysphagia and weight loss. A krukenberg tumour kt is defined as an ovarian metastasis from a gastrointestinal adenocarcinoma and suggests a terminal condition. Clinical analysis of krukenberg tumours in patients with. Weight loss and persistent abdominal pain are the most common symptoms at initial diagnosis table 1 1.
Krukenbergs tumor definition of krukenbergs tumor by. Metastatic factors of 43 cases of metachronous krukenberg tumor were analyzed with univariate and multivariate methods. Pathways of metastases from primary organs to the ovaries. Krukenberg tumors are defined as gastrointestinal cancers that metastasize to the ovary. A case of krukenberg tumor metastasized from colon cancer. Since the time of krukenberg in 1896, all ovarian tumors which enlarge the ovaries uniformly without distortion, which present alterations of fibrous areas with mucinouscell groups, and which propagate along the lymphatics are called krukenberg tumors 6. Krukenberg tumor article about krukenberg tumor by the. Pseudomeigs syndrome caused by a krukenberg tumour of gastric cancer article pdf available in internal medicine 5420. The development of the krukenberg tumor is not from general gastric cancer, but it is a specific form of cancerous growth arises from signet ring cell carcinoma of the stomach and spread to adenocarcinoma of the ovary the primary place of development of the krukenberg tumor is the stomach, but other primary.
The route of metastatsis of this rare condition is still not proven. Pubmed is a searchable database of medical literature and lists journal articles that discuss krukenberg carcinoma. She was referred recurrent cholangiocarcinoma presenting as ovarian krukenberg tumor chuanchi shih 1, yuhcheng yang 1,2,3,4, jerry chengyen lai 4, yuhui huang 1, taoyeuan wang 5, kungliahng wang 1,3,6 1 department of obstetrics and gynecology, mackay memorial hospital, 2 taipei medical university, 3 mackay medicine, nursing and. Tumor krukenberg merupakan tumor primer yang dapat metastasis ke ovarium, berasal dari. This study aims to describe the unusual case of a 36yearold woman that presented to the emergency department ed with back pain and a positive urine pregnancy test. The aim of this study is to compare the each clinical manifestation related with its mean survival time of krukenberg tumors kts of gastric origin versus with that of colorectal origin. Clinical characteristics and prognostic analysis of. The ovarian lesions were histologically diagnosed as krukenberg tumor metastasized from. H major revealed the true metastatic nature of the tumor. Krukenberg tumor, also known as carcinoma mucocellulare, refers to the signet ring subtype of metastatic tumor to the ovary. Krukenberg tumors are metastatic signetring cell adenocarcinomas of the ovary. Krukenberg tumor life expectancy doctor answers on. Krukenberg tumor survival rate, prognosis, symptoms. We describe a patient with a metastatic krukenberg tumor caused by an occult primary gastric cancer that was found during an.
Krukenbergs tumorsaremetastatic tumorsoftheovarythat account for510% ofovarian tumors andthatcausemajor problems inradiologic orpathologic diagnosis 5. This article provides an overview of the major pathologic manifestations of krukenberg tumor, patient characteristics, clinical and laboratory features of the disease, prognostic factors, and current knowledge about its pathogenesis. Medical records of patients who had received cytoreductive surgery and had been pathologically diagnosed. Krukenberg tumor presenting as back pain and a positive. The term krukenberg tumor refers to metastatic disease to the ovary and more specifically those metastases containing mucinsecreting signet cells. These tumors occur with greatest frequency in women about the age of thirtyfive. Krukenberg tumor in a 22 year old patient with primary. Initially thought to be unusual primary malignancies by krukenberg himself, were later recognized as metastatic lesions usually arising from primary cancers of the gastrointestinal tract, especially the stomach and colon. Krukenberg tumors are uncommon and account for 1% to 2% of all ovarian tumors. Recurrent cholangiocarcinoma presenting as ovarian. A bilateral adnexectomy at another hospital revealed involvement of both ovaries, and immunohistochemistry revealed that the tumor was ck7. An adnexal mass in pregnancy is a malignant tumor in 25% of cases. Krukenberg tumor is more commonly observed among women in their fifth decade of lives, with an average around 45 years of age.
The factors of poor prognosis in our patients are the late diagnosis, presence of ascites and age of. Krukenbergtumor academic dictionaries and encyclopedias. Krukenberg tumor is named after friedrich ernst krukenberg who described five cases of krukenberg tumors in 1896 while working as a student in a laboratory in germany. Mucocellular carcinoma of the ovary, usually metastatic from the gastrointestinal tract, characterized by areas of mucoid degeneration and the presence of signetringlike cells. Gastric adenocarcinoma, especially at the pylorus, is the most common source. Krukenberg tumor is usually but not always a bilateral involvement of ovaries from metastatic deposit from adenocarcinoma of stomach and rarely from other gastrointestinal gi and non gi organs. The sustained interest in the type of our own case strengthens the conviction tumor first described by krukenberg that the krukenberg tumor is metastatic, in 1896, the socalled fibrosarcoma that clinical methods of diagnosis still fig. Krukenberg tumor arising from bilateral lobular carcinoma. In this case, the treatment is guided by histopathological findings. It is still uncertain whether surgical resection of ovarian metastases andor primary tumor could improve the outcome. Krukenberg tumor medical definition merriamwebster. Krukenberg tumor is a rare tumor accounting for 12% of all ovarian tumors alagha, 2006.
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